Effective treatment of advanced solid tumors by the combination of arsenic trioxide and L-buthionine-sulfoximine
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چکیده
منابع مشابه
Enhancement of arsenic trioxide-induced apoptosis in HeLa cells by diethyldithiocarbamate or buthionine sulfoximine.
Arsenic trioxide (ATO) affects many biological functions such as cell proliferation, apoptosis, differentiation and angiogenesis in various cells. We investigated the in vitro effects of ATO as a reactive oxygen species (ROS) generator or a glutathione (GSH) depletor on apoptosis in HeLa cells. ATO decreased the viability of HeLa cells in a dose-dependent manner with an IC50 of approximately 5-...
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Glutathione depletion by L-buthionine sulfoximine antagonizes taxol cytotoxicity.
Taxol is a naturally occurring chemotherapeutic agent that is active against a variety of tumors. Taxol is believed to act by binding tightly to microtubules and preventing their disaggregation. Others have shown that depletion of cellular glutathione results in the disaggregation of microtubules, presumably by allowing the oxidation of some or all of the cysteine residues in tubulins. We studi...
متن کاملArsenic trioxide treatment decreases the oxygen consumption rate of tumor cells and radiosensitizes solid tumors.
Arsenic trioxide (As(2)O(3)) is an effective therapeutic against acute promyelocytic leukemia and certain solid tumors. Because As(2)O(3) inhibits mitochondrial respiration in leukemia cells, we hypothesized that As(2)O(3) might enhance the radiosensitivity of solid tumors by increasing tumor oxygenation [partial pressure of oxygen (pO(2))] via a decrease in oxygen consumption. Two murine model...
متن کاملVascular Disrupting Agent Arsenic Trioxide Enhances Thermoradiotherapy of Solid Tumors
Our previous studies demonstrated arsenic trioxide- (ATO-) induced selective tumor vascular disruption and augmentation of thermal or radiotherapy effect against solid tumors. These results suggested that a trimodality approach of radiation, ATO, and local hyperthermia may have potent therapeutic efficacy against solid tumors. Here, we report the antitumor effect of hypofractionated radiation f...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2004
ISSN: 1350-9047,1476-5403
DOI: 10.1038/sj.cdd.4401389